|
KMID : 0606920180260060568
|
|
Biomolecules & Therapeutics
2018 Volume.26 No. 6 p.568 ~ p.575
|
|
|
Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans
|
|
Lee Eun-Byeol
Kim Jun-Hyeong
An Chang-Wan
Kim Yeong-Jee
Noh Yun-Jeong
Kim Su-Jin
Kim Ju-Eun
Shrestha Abinash Chandra
Ham Ha-Neul
Leem Jae-Yoon
Jo Hyung-Kwon
Kim Dae-Sung
Moon Kwang-Hyun
Lee Jeong-Ho
Jeong Kyung-Ok
Kim Dae-Keun
|
|
|
Abstract
|
|
|
|
In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans, and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
|
|
|
KEYWORD
|
|
|
Zingiber officinale Roscoe, 6-Gingerol, Caenorhabditis elegans, Longevity, Stress tolerance
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|